Alexander Moskalensky

Alexander Moskalensky, head of laboratory

Welcome to my personal page! My name is Alexander Moskalensky, I'm head of Laboratory of Optics and Dynamics of Biological Systems of Novosibirsk State University (Russia).

My research is devoted to the understanding of dynamic processes in biology using optical experimental approaches and biophysical simulations. My laboratory advances biophotonics in a more general sense, including light-induced therapy.

Education and Professional Experience

  • Bachelor of Science in physics, biomedical physics chair, department of physics, NSU, 2010
  • Master of Science in physics, biomedical physics chair, department of physics, NSU, 2012
  • PhD in Biophysics, 2015. Thesis title (translated): “Investigation of the optical properties of resting and activated blood platelets and their aggregates with the scanning flow cytometry”.

I received the scientific part of my education (the most important part when studying at the department of physics in NSU) in the Laboratory of Cytometry and Biokinetics in Voevodsky Institute of Chemical Kinetics and Combustion SB RAS. I'm very thankful to Prof. Valery P. Maltsev (head of laboratory) and Dr. Maxim A. Yurkin for their wise and stimulating scientific supervision.

I worked as a researcher in the Laboratory of Cytometry and Biokinetics from 2012 (now part-time); From 2016 I moved to a NSU to lead a lab conducting research in biophotonics, and I'm grateful to Prof. Sergei Turitsyn for this opportunity.

My international experience:

  • Marie Curie International Research Staff Exchange Scheme:
    • 2011 – training in Institute of Biophysics, Brno, Czech republic;
    • 2012 training in biotechnology department of Jagellonian University, Krakow, Poland
  • Erasmus+ mobility program:
    • 2018 – training in Aston University, Birmingham, UK
  • Attended conferences in Europe, USA and China - one or two per year starting from 2012.

Teaching:

  • Since 2012: seminars in molecular physics (1st year physicists)
  • Since 2017: seminars in “elementary physics” (1st year biologists)
  • Since 2019: lectures “Introduction to Biophotonics” (Master students)

I've been a scientific supervisor for a number of students of the Department of Physics of NSU.

Research projects

  • Russian Science Foundation Project #23-75-10049: "Study of platelet activation by combined stimuli using optically induced generation of ligands" - 2023-2025
  • Grant of the President of Russian Fedaration for state support of young Russian scientists МК-4020.2021.1.2: "New photoactive compounds to combat novel coronavirus disease (COVID-19) using methods of biophotonics" - 2021-2022
  • Russian Science Foundation Project #18-15-00049: "Dynamic study of platelets and leukocytes activation to reveal cellular mechanisms of microvascular diabetes complications and develop novel non-invasive therapy strategies" - 2018-2020; prolongation - 2021-2022
  • Grant of the President of Russian Fedaration for state support of young Russian scientists МК-1715.2018.2: "Development of photonic technologies to manage status and properties of biological cells" - 2018-2019

Peer-reviewed journal papers

28. Natalia A. Virts, Tatyana Yu. Karogodina, Mikhail A. Panfilov, Alexey Yu. Vorob’ev, Alexander E. Moskalensky, Nitric Oxide Photorelease from Silicone Films Doped with N-Nitroso BODIPY, Journal of Functional Biomaterials, 15(4), 92 (2024) https://doi.org/10.3390/jfb15040092

27. Mikhail A. Panfilov, Tatyana Yu. Karogodina, Anastasiya A. Sibiryakova, Irina S. Tretyakova, Alexey Yu. Vorob'ev, Alexander E. Moskalensky, Meso-Aminomethyl-BODIPY as a Scaffold for Nitric Oxide Photo-Releasers, ChemistrySelect, 8, e202302681 (2023) https://doi.org/10.1002/slct.202302681

26. Darya N. Litunenko, Alexander E. Moskalensky, Wireless monitoring of cell cultures based on light scattering: A novel optical scheme and portable prototype, Journal of Biophotonics, e202300234 (2023) https://doi.org/10.1002/jbio.202300234

25. Zhermolenko E.O., Karogodina T.Yu., Vorobev A.Yu., Panfilov M.A., Moskalensky A.E., Photocontrolled release of nitric oxide for precise management of NO concentration in a solution, Materials Today Chemistry, 29, 101445 (2023). https://doi.org/10.1016/j.mtchem.2023.101445

24. Darya N. Litunenko, Tatyana Yu. Karogodina, Alexey Yu. Vorob’ev, Alexander E. Moskalensky. Novel UV-Releaser of Arachidonic Acid Based on Nitrophenyl-type Photoremovable Protecting Group, Journal of Biomedical Photonics & Engineering 8, 3, #3498 (2022). https://doi.org/10.18287/JBPE22.08.030305

23. Mikhail A.Panfilov, Tatyana Yu.Karogodina, YaoSongyin, Oleg Yu.Karmatskih, Alexey Yu.Vorob'ev, Irina S.Tretyakova, Evgeni M.Glebov, Alexander E.Moskalensky, Photophysical properties of BODIPYs with sterically-hindered nitrophenyls in meso-position, Journal of Luminescence 246, 118837 (2022). https://doi.org/10.1016/j.jlumin.2022.118837

22. Zobnina, A., Moskalensky, A., Vorob’ev, A. , 8-[4-(2-Hydroxypropane-2-yl)Phenyl]-1,3,4,4,5,7-Hexamethyl-4-Boron-3a,4a-Diaza-S-Indacene, Molbank M1286 (2021). https://doi.org/10.3390/M1286

21. Mikhail Panfilov, Darya Chernova, Irina Khalfina, Alexander Moskalensky, Aleksey Vorob’ev, Design and Synthesis of New Acridone-Based Nitric Oxide Fluorescent Probe, Molecules (2021). https://doi.org/10.3390/molecules26144340

20. Alexander E Moskalensky, Tatyana Yu Karogodina, Alexey Yu Vorobev, Sergei G Sokolovski, Singlet oxygen luminescence detector based on low-cost InGaAs avalanche photodiode, HardwareX (2021). https://doi.org/10.1016/j.ohx.2021.e00224

19. Alena L Litvinenko, Vyacheslav M Nekrasov, Dmitry I Strokotov, Alexander E Moskalensky, Andrei V Chernyshev, Anna N Shilova, Andrey A Karpenko, Valeri P Maltsev, Blood platelet quantification by light scattering: from morphology to activation, Analytical Methods (2021). https://doi.org/10.1039/D1AY00431J

18. Alexander E Moskalensky and Maxim A Yurkin, A point electric dipole: From basic optical properties to the fluctuation-dissipation theorem, Reviews in Physics (2021). https://doi.org/10.1016/j.revip.2020.100047

17. Dranova, T.Y., Vorobev, A.Y., Pisarev, E.V., Moskalensky, A.E., Diaminorhodamine and Light-Activatable NO Donors: Photorelease Quantification and Potential Pitfalls, Journal of Fluorescence (2021). https://doi.org/10.1007/s10895-020-02643-7

16. Darya V. Spiryova, Alexei Yu. Vorobev, Vadim V. Klimontov, Elena A. Koroleva, and Alexander E. Moskalensky, Optical uncaging of ADP reveals the early calcium dynamics in single, freely moving platelets, Biomedical Optics Express 11:6, pp. 3319-3330 (2020). https://doi.org/10.1364/BOE.392745

15. Vorobev A. Yu and Moskalensky A.E., Long-wavelength photoremovable protecting groups: On the way to in vivo application, Computational and Structural Biotechnology Journal 18: 27-34 (2020). https://doi.org/10.1016/j.csbj.2019.11.007

14. Vorob'ev A. Yu, Dranova T. Yu and Moskalensky A.E., Photolysis of dimethoxynitrobenzyl-“caged” acids yields fluorescent products, Scientific Reports 9(1):13421 (2019). https://doi.org/10.1038/s41598-019-49845-z

13. Moskalensky A.E. and Yurkin M.A. Energy budget and optical theorem for scattering of source-induced fields, Phys. Rev. A 99, 053824 (2019). https://doi.org/10.1103/PhysRevA.99.053824

12. A.E. Moskalensky, A.L. Litvinenko, The platelet shape change: biophysical basis and physiological consequences, Platelets 30:5, pp. 543-548. https://doi.org/10.1080/09537104.2018.1514109

11. Peter Brown, RELISH Consortium , Yaoqi Zhou, “Large expert-curated database for benchmarking document similarity detection in biomedical literature search”, Database, Volume 2019, baz085 (2019), https://doi.org/10.1093/database/baz085

10. Khalo I.V., Kozyreva V.S., Vakhrushev R.V., Patlai D.S., Shilova A.N., Karpenko A.A., Yurkin M.A., Moskalensky A.E., Strokotov D.I., Maltsev V.P., and Chernyshev A.V. Calibration-free quantitative immunoassay by flow cytometry: Theoretical consideration and practical implementation for IgG antibody binding to CD14 receptors on human leukocytes, Cytometry A 93, 695–705 (2018). https://doi.org/10.1002/cyto.a.23494

9. A.E. Moskalensky, M.A. Yurkin, A.R. Mulyukov, A.L. Litvinenko, V.M. Nekrasov, A.V. Chernyshev, V.P. Maltsev, Method for the simulation of blood platelet shape and its evolution during activation, PLoS Computational Biology. 14(3):e1005899. https://doi.org/10.1371/journal.pcbi.1005899

8. Litvinenko A.L., Moskalensky A.E., Karmadonova N.A., Nekrasov V.M., Strokotov D.I., Konokhova A.I., Yurkin M.A., Pokushalov E.A., Chernyshev A.V., and Maltsev V.P. Fluorescence-free flow cytometry for measurement of shape index distribution of resting, partially activated, and fully activated platelets, Cytometry A 89, 1010–1016 (2016). https://doi.org/10.1002/cyto.a.23003

7. Konokhova A.I., Chernova D.N., Moskalensky A.E., Strokotov D.I., Yurkin M.A., Chernyshev A.V., and Maltsev V.P. Super-resolved calibration-free flow cytometric characterization of platelets and cell-derived microparticles in platelet-rich plasma, Cytometry A 89, 159–168 (2016). https://doi.org/10.1002/cyto.a.22621

6. Moskalensky A.E., Chernyshev A.V., Yurkin M.A., Nekrasov V.M., Polshchitsin A.A., Parks D.R., Moore W.A., Filatenkov A., Maltsev V.P., and Orlova D.Y. Dynamic quantification of antigen molecules with flow cytometry, J. Immunol. Meth. 418, 66–74 (2015). http://doi.org/10.1016/j.jim.2015.02.001

5. Konokhova A.I., Rodionov A.A., Gilev K.V., Mikhaelis I.M., Strokotov D.I., Moskalensky A.E., Yurkin M.A., Chernyshev A.V., and Maltsev V.P. Enhanced characterisation of milk fat globules by their size, shape and refractive index with scanning flow cytometry, Int. Dairy J. 39, 316–323 (2014). http://doi.org/10.1016/j.idairyj.2014.08.006

4. Moskalensky A.E., Strokotov D.I., Chernyshev A.V., Maltsev V.P., and Yurkin M.A. Additivity of light-scattering patterns of aggregated biological particles, J. Biomed. Opt. 19, 085004 (2014). http://doi.org/http://doi.org/10.1117/1.JBO.19.8.085004

3. Moskalensky A.E., Yurkin M.A., Konokhova A.I., Strokotov D.I., Nekrasov V.M., Chernyshev A.V., Tsvetovskaya G.A., Chikova E.D., and Maltsev V.P. Accurate measurement of volume and shape of resting and activated blood platelets from light scattering. J. Biomed. Opt. 18, 017001 (2013). http://doi.org/10.1117/1.JBO.18.1.017001

2. Konokhova A.I., Yurkin M.A., Moskalensky A.E., Chernyshev A.V., Tsvetovskaya G.A., Chikova E.D., and Maltsev V.P. Light-scattering flow cytometry for identification and characterization of blood microparticles. J. Biomed. Opt. 17, 057006 (2012). http://doi.org/10.1117/1.JBO.17.5.057006

1. Dmitry I. Strokotov Alexander E. Moskalensky Vyacheslav M. Nekrasov Valeri P. Maltsev. Polarized light‐scattering profile—advanced characterization of nonspherical particles with scanning flow cytometry, Cytometry A, 79(7):570-9 (2011). https://doi.org/10.1002/cyto.a.21074

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